urn:ieda:metadataabout:10.15784-600118
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dataset
Dataset
Interdisciplinary Earth Data Alliance
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ISO 19139 Geographic Information - Metadata - Implementation Specification
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The Cellular Stress Response in Cold-adapted Organisms: Building Novel Mechanistic Links between Heat Stress, Cell Cycle Arrest and Apoptosis in Antarctic Fishes.
2013
publication
doi:10.15784/600118
Buckley, Bradley
Portland State University, Portland, OR, 97207, US
bbuckley@pdx.edu
author
U.S. Antarctic Program (USAP) Data Center
publisher
Abstract: The research will investigate a novel mechanism by which cold-adapted fishes of the Southern Ocean sense and respond to elevated temperatures. It is hypothesized that sub-lethal heat stress may induce cell cycle arrest and/or programmed cell death through apoptosis. The study will use genome-enabled technologies to examine the environmental control over gene expression in Antarctic species and will build direct mechanistic links between the expression of a specific signaling pathway gene and heat-induced changes in cells. Prior results support the hypothesis that heat stress results in cell cycle arrest and, in some cases, programmed cell death in Antarctic fishes. If so, this represents a novel, modified version of the well-conserved cellular stress response found in essentially all other species and suggests that warming ocean temperatures may have profound cellular and physiological impacts on these extremely stenothermal species. The P.I. conducts outreach activities with the Oregon Museum of Science and Industry, will be involved in developing a science curriculum for the Native American Youth and Family Center (NAYA) Early College Academy in Portland, and supports the educational and professional development of both undergraduate and graduate students at Portland State University.
funderName:NSF:GEO:PLR:Antarctic Organisms and Ecosystems
awardNumber:0944743
awardTitle:The Cellular Stress Response in Cold-adapted Organisms: Building Novel Mechanistic Links between Heat Stress, Cell Cycle Arrest and Apoptosis in Antarctic Fishes.
Complete
Buckley, Bradley
Portland State University, Portland, OR, 97207, US
pointOfContact
Antarctic Organisms and Ecosystems
program
Biology
IEDA data type categories
IEDA integrated catalog keyword vocabulary
2017-10-11
creation
Southern Ocean
IEDA feature of interest
IEDA integrated catalog keyword vocabulary
2017-10-11
creation
Biosphere
IEDA topic
IEDA integrated catalog keyword vocabulary
2017-10-11
creation
US Antarctic Program Data Center (USAP-DC)
Data Center
Creative Commons Attribution-NonCommercial-Share Alike 3.0 United States [CC BY-NC-SA 3.0]
Creative Commons Attribution-NonCommercial-Share Alike 3.0 United States [CC BY-NC-SA 3.0]
eng
geoscientificInformation
-77.83333 166.66667
2010-08-15
2013-07-31
http://dx.doi.org/10.15784/600118
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http://www.usap-dc.org/view/dataset/600118
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This metadata record was generated by an xslt transformation from a DataCite metadata record; The transform was created by Damian Ulbricht and Stephen M. Richard. 2017-11-15 these records include new IEDA keywords for geoportal facets Run on 2018-06-21T19:05:24-07:00
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